Acne No More Review - Review About The Signs of Acne

Establishing the influence of hormonal status on the course of acne in some cases is an important element in the diagnosis of acne. Thus, the definition of free testosterone -sulfate, luteinizing hormone just shows women with symptoms: hirsutism, irregular menstruation, alopecia, with the development of acne in period or during late manifestation of acne (after 25 years), as well as treatment failure severe acne with isotretinoin.
In cases resistant to therapy and explore the levels of other hormones, progesterone, pituitary hormones. Significant role in the development of acne is withdrawn pathological follicular canal. Normally, in the lumen there is a thin layer consisting of easily rejects corneocyte. Acne rejection process is slowed down as a result of violations of the qualitative or quantitative composition of intercellular lipids, and as a result of insufficient disintegration of desmosomes of keratinocytes in the stratum .

This leads to disruption of normal exfoliation of corneocytes and promotes retention hyperkeratosis, which is against the background of the strong cohesion of corneocytes ultimately promotes clogging of the sebaceous glands and the formation of horny masses microcomedo. If the outlet openings of the sebaceous glands are dilated (with hyperkeratosis), formed open comedones, which visually appear as small black head with a diameter of 1-3 mm.

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When hyperkeratosis not occur expansion pin holes, and closed comedones are formed, they look like little white heads up to 2 mm in diameter. Closed comedones are transformed into cells or inflammatory, gradually increasing in volume, turn into open comedones. Blockage of ducts of the sebaceous glands leads to the cessation of air in their cavity, which creates conditions for rapid multiplication propionibacterium acne. Propionibacterium acne, in turn, plays an important role in the formation of comedones and inflammatory reactions in their rash. This is facilitated by a number of factors:

Propionibacterium acne synthesize, easily penetrating through the wall of the follicle and attracting white blood cells that form the infiltrate around the follicle and are involved in the release of lysosomal enzymes that damage from the outside wall of the follicle; propionbakterii acne synthesize lipase splits triglycerides sebum to free fatty acids that damage the follicle wall from the inside; directly or indirectly damaging the follicle wall, propionibacterium acne facilitate contact comedone content with the surrounding tissue, causing inflammation, which may take the form of both surface rash and deep nodes.

The number of bacteria in the rash does not correlate with disease severity. If pimples and rashes are characterized by a high degree of contamination propionibacterium acne, the nodular formation of their number is minimal. This is due to the generation of oxygen by leukocytes, detrimental effect on anaerobic microorganisms, as well as propionibacterium acne surrounding cells.